| Player | Total Sixes | Career Runs | Team |
| Chris Gayle | 87 | 1406 | West Indies / ICC World XI |
| Brendon McCullum | 87 | 2105 | New Zealand |
| Shane Watson | 69 | 1156 | Australia |
| David Warner | 66 | 1444 | Australia |
| Yuvraj Singh | 63 | 968 | India |
| Shahid Afridi | 51 | 1165 | Pakistan / ICC World XI |
| Martin Guptill | 50 | 1273 | New Zealand |
| Marlon Samuels | 46 | 941 | West Indies |
| Jean-Paul Duminy | 44 | 1406 | South Africa |
| Ross Taylor | 44 | 1120 | New Zealand |
| Eoin Morgan | 44 | 1147 | Ireland |
| Cameron White | 44 | 984 | Australia |
| Dwayne Bravo | 41 | 936 | West Indies |
| Albie Morkel | 39 | 572 | South Africa |
| Umar Akmal | 38 | 1293 | Pakistan |
| David Hussey | 34 | 756 | Australia |
| Kieron Pollard | 34 | 633 | West Indies |
| Alex Hales | 34 | 1062 | England |
| Suresh Raina | 34 | 947 | India |
| Mohammad Hafeez | 33 | 1354 | Pakistan |
| Mahela Jayawardene | 33 | 1493 | Sri Lanka / Asian XI |
| Aaron Finch | 32 | 756 | Australia |
| Kevin Pietersen | 32 | 1176 | England / ICC World XI |
| Luke Wright | 31 | 759 | England |
| Dwayne Smith | 31 | 582 | West Indies |
| AB de Villiers | 30 | 1007 | South Africa / Africa XI |
| Elton Chigumbura | 29 | 539 | Zimbabwe |
| Tillakaratne Dilshan | 27 | 1466 | Sri Lanka |
| Darren Sammy | 27 | 511 | West Indies |
| Kamran Akmal | 27 | 897 | Pakistan |
| Rohit Sharma | 27 | 739 | India |
| Graeme Smith | 26 | 982 | South Africa / Africa XI |
| Hamilton Masakadza | 26 | 915 | Zimbabwe |
| Lendl Simmons | 26 | 761 | West Indies |
| Misbah-ul-Haq | 26 | 788 | Pakistan |
| Scott Styris | 25 | 578 | New Zealand |
| Michael Hussey | 25 | 721 | Australia |
| Paul Collingwood | 24 | 583 | England |
| MS Dhoni | 24 | 849 | India |
| Thisara Perera | 23 | 466 | Sri Lanka |
| Faf du Plessis | 23 | 710 | South Africa |
| Craig Kieswetter | 23 | 526 | England |
| James Franklin | 23 | 463 | New Zealand |
| Sanath Jayasuriya | 23 | 629 | Sri Lanka / Asian XI |
| Jacob Oram | 22 | 474 | New Zealand |
| Kushal Perera | 22 | 521 | Sri Lanka |
| Imran Nazir | 22 | 500 | Pakistan |
| Glenn Maxwell | 22 | 343 | Australia |
| Michael Lumb | 21 | 552 | England |
| Ahmed Shehzad | 21 | 799 | Pakistan |
