| Player | Total Fours | Career Runs | Team |
| Brendon McCullum | 197 | 2105 | New Zealand |
| Mahela Jayawardene | 173 | 1493 | Sri Lanka / Asian XI |
| Tillakaratne Dilshan | 171 | 1466 | Sri Lanka |
| Mohammad Hafeez | 142 | 1354 | Pakistan |
| Kumar Sangakkara | 139 | 1382 | Sri Lanka / Asian XI |
| David Warner | 137 | 1444 | Australia |
| Graeme Smith | 123 | 982 | South Africa / Africa XI |
| Chris Gayle | 122 | 1406 | West Indies / ICC World XI |
| Kevin Pietersen | 119 | 1176 | England / ICC World XI |
| Martin Guptill | 112 | 1273 | New Zealand |
| Alex Hales | 112 | 1062 | England |
| Gautam Gambhir | 109 | 932 | India |
| Jean-Paul Duminy | 108 | 1406 | South Africa |
| Virat Kohli | 105 | 972 | India |
| Eoin Morgan | 102 | 1147 | Ireland |
| Umar Akmal | 100 | 1293 | Pakistan |
| Shahid Afridi | 91 | 1165 | Pakistan / ICC World XI |
| Kamran Akmal | 90 | 897 | Pakistan |
| Shane Watson | 88 | 1156 | Australia |
| Tamim Iqbal | 87 | 716 | Bangladesh |
| Shakib Al Hasan | 87 | 809 | Bangladesh |
| Ahmed Shehzad | 86 | 799 | Pakistan |
| Suresh Raina | 86 | 947 | India |
| Hamilton Masakadza | 85 | 915 | Zimbabwe |
| Aaron Finch | 83 | 756 | Australia |
| AB de Villiers | 82 | 1007 | South Africa / Africa XI |
| Shoaib Malik | 78 | 973 | Pakistan |
| William Porterfield | 77 | 627 | Ireland |
| Sanath Jayasuriya | 76 | 629 | Sri Lanka / Asian XI |
| Paul Stirling | 76 | 584 | Ireland |
| Marlon Samuels | 75 | 941 | West Indies |
| Lendl Simmons | 73 | 761 | West Indies |
| Ross Taylor | 72 | 1120 | New Zealand |
| Mohammad Shahzad | 72 | 663 | Afghanistan |
| Cameron White | 71 | 984 | Australia |
| Hashim Amla | 70 | 600 | South Africa |
| Luke Wright | 68 | 759 | England |
| Faf du Plessis | 67 | 710 | South Africa |
| Salman Butt | 66 | 594 | Pakistan |
| Michael Lumb | 64 | 552 | England |
| Dwayne Smith | 62 | 582 | West Indies |
| Rohit Sharma | 61 | 739 | India |
| Yuvraj Singh | 61 | 968 | India |
| Johnson Charles | 59 | 429 | West Indies |
| Imran Nazir | 59 | 500 | Pakistan |
| Michael Hussey | 58 | 721 | Australia |
| MS Dhoni | 57 | 849 | India |
| Jacques Kallis | 56 | 666 | South Africa / ICC World XI |
| Dwayne Bravo | 55 | 936 | West Indies |
| Ravi Bopara | 54 | 711 | England |
